Short Intertrial Intervals Impair Water Maze Performance in Old Fischer 344 Rats
نویسندگان
چکیده
منابع مشابه
Exogenous NGF affects cholinergic transmitter function and Y-maze behavior in aged Fischer 344 male rats.
Chronic ICV administration of NGF stimulates the activity of the cholinergic neuronal markers, HACU and ChAT, as well as the evoked release of both endogenous and newly synthesized acetylcholine in the brain of aging Fischer 344 male rats. However, the pattern of cholinergic phenotype stimulation indicates an age-related differential regulation of ChAT, HACU, and ACh release between specific br...
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The aging process is characterized by a series of changes in neurochemical functioning and in motor and cognitive performance. In addition to changes in cognitive/behavioral performance, aged rats also show an increase in baseline anxiety measured using the elevated plus-maze. Exposure to Fe particles, a component of cosmic rays, produces neurochemical and behavioral changes in young animals wh...
متن کاملHigher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats.
Dopamine (DA) and D1-like receptor agonists promote an increase in Na excretion by means of activation of the D1-like receptor signaling cascade and subsequent inhibition of the Na/H exchanger and Na-K-ATPase in renal proximal tubules. Recently, our laboratory reported that DA and the D1-like receptor agonist failed to inhibit Na-K-ATPase activity in old Fischer 344 rats because of uncoupling o...
متن کاملMuscle adaptations to hindlimb suspension in mature and old Fischer 344 rats.
We examined skeletal and cardiac muscle responses of mature (8 mo) and old (23 mo) male Fischer 344 rats to 14 days of hindlimb suspension. Hexokinase (HK) and citrate synthase (CS) activities and GLUT-4 glucose transporter protein level, which are coregulated in many instances of altered neuromuscular activity, were analyzed in soleus (Sol), plantaris (PI), tibialis anterior (TA), extensor dig...
متن کاملBrief dietary restriction increases skeletal muscle glucose transport in old Fischer 344 rats.
The primary purpose of this study was to determine the impact of brief dietary restriction (DR; 5 or 20 days) on skeletal muscle glucose transport activity (GTA) of 24-month-old female Fischer 344 rats. Basal GTA of isolated epitrochlearis muscles was unaffected by DR. Insulin-stimulated GTA was significantly increased by DR only at 20 days (51%). We also assessed the influence of DR on energy ...
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ژورنال
عنوان ژورنال: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
سال: 1996
ISSN: 1079-5006,1758-535X
DOI: 10.1093/gerona/51a.4.b253